Open AccessExploration of Antioxidant, Antibacterial Activities of Green Synthesized Hesperidin Loaded PLGA Nanoparticles
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac116.1452014528
Subject(s) - plga , hesperidin , chemistry , antioxidant , enterobacter aerogenes , antibacterial activity , dpph , antimicrobial , pseudomonas aeruginosa , hydrogen peroxide , silver nanoparticle , nanoparticle , biochemistry , nanotechnology , escherichia coli , bacteria , materials science , organic chemistry , in vitro , biology , medicine , genetics , alternative medicine , pathology , gene
To elaborate on the potential benefits of hesperidin loaded PLGA nanoparticles (HES-PLGA NPs), present investigation reports about the antioxidant, antimicrobial, and cytotoxic potential of hesperidin loaded PLGA nanoparticles (HES-PLGA-NPs). The antioxidant potential of Hesperidin and HES-PLGA-NPs was demonstrated by ATBS, DPPH, Hydroxy, Hydrogen peroxide, and superoxide radical showing the dose-dependent antioxidants activity. Both the test gained better potential with HES loaded PLGA nanoparticles than free HES. HES-PLGA-NPs also proved its antibacterial activity against tested bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Pseudomonas aeruginosa. HES-PLGA-NPs had a good ability to minimize biofilms' formation and a good to weak ability to degrade pre-formed biofilms. Thus, the bionanotherapy, which has been attempted using HES-PLGA-NPs would provide a promising scope as a potent bio compound that can be replaced for medical ailments in a cost-effective, greener synthesis.