Open AccessA NMR Study of Sodium/Potassium Pumping System in the Node of Ranvier Myelin-Sheath
Author(s) -
Narges Najaflou,
Majid Monajjemi
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac116.1426014277
Subject(s) - node of ranvier , myelin sheath , ion channel , chemistry , membrane , myelin , biophysics , sodium channel , potassium , capacitive sensing , membrane potential , voltage , sodium , electrophysiology , nuclear magnetic resonance , neuroscience , physics , biochemistry , electrical engineering , biology , engineering , receptor , organic chemistry , central nervous system
The QM/MM calculation has been applied to generalize the node of Ranvier results for computing action potentials and electrochemical behavior of membranes that agree with clusters of voltage-gated ion sodium and potassium channels. Ranvier complexes' node is an accurate organization of membrane-bound aqueous boxes. The model applied here shows an electrophysiological phenomenon with simulated structural and physiological data. The quantum effects of various thicknesses in a selected membrane of Galc /DMPC and Galc/NPGS have also been specifically investigated. This allows introducing a capacitive susceptibility that can resonate with the self-induction of helical coils or ion channels, the resonance of which is the main reason for various biological pulses.
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