Regulatory Gene Network Pathway among Brain Cancer and Associated Disease: a Computational Analysis

Brain cancer (BC), melanoma (ML), bladder cancer (BDC), benign tumor (BT), gliomas (GM) are annihilating diseases among people because of their high death risk. These five diseases are associated among themselves. The analysis shows that there are eight common genes TERT, MYC, GSTP1, GSTM1, CXCR4, CXCL12, GSTT1, PROM1, among those associated with five diseases. Preprocessing has been done to find these eight common genes based on biological, biochemical, and genetic relationships between common genes. This analysis identifies the most significant hub proteins. Seed, nodes, and edges create networks that indicate the relationship between the genes and proteins. Protein-protein interaction (PPIs) network, TF –gene interactions, gene regulatory network (GRN), protein-drug, protein-chemical, gene-diseases analysis has been done the common genes and their interactions, correlation, association, and candidate drugs. Topological analysis finally provides eight common genes that can develop an efficient drug design for this research.