Open AccessSynthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives
Author(s) -
Erdal Kocabaş,
Ahmet Burak Sarıgüney,
Fatih Erci,
Rabia Çakır-Koç,
Hilal Kocabaş,
Emrah Torlak,
Ahmet Coşkun
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac114.1217812185
Subject(s) - bacillus cereus , thiazole , pyrrolidine , staphylococcus aureus , escherichia coli , broth microdilution , chemistry , antibacterial activity , minimum inhibitory concentration , cytotoxicity , bacteria , combinatorial chemistry , microbiology and biotechnology , antimicrobial , stereochemistry , organic chemistry , in vitro , biochemistry , biology , genetics , gene
In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and 1H NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.