Open AccessMelanogenesis, Its Regulatory Process, and Insights on Biomedical, Biotechnological, and Pharmacological Potentials of Melanin as Antiviral Biochemical
Author(s) -
Toluwase Hezekiah Fatoki,
Omodele Ibraheem,
Catherine Joke Adeseko,
AJ Lawrence,
Daniel Uwaremhevho Momodu,
David Morakinyo Sanni,
Jesupemi Mercy Enibukun,
Ibukun Oladejo Ogunyemi,
Adewunmi Adeoye,
Harriet U. Ugboko,
Amoge Chidinma Ogu,
Abiodun Samuel Oyedele,
Adejoju Omodolapo Adedara,
Abiodun Joseph Jimoh,
Oluwakemi Ruth Ogundana,
Oritsetimeyin Eworitse Ebosa
Publication year - 2020
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac114.1196911984
Subject(s) - biology , melanin , creb , microphthalmia associated transcription factor , tyrosinase , transcription factor , pharmacology , microbiology and biotechnology , biochemistry , gene , enzyme
Melanin is s most widely distributed pigment and is found in bacteria, fungi, plants, and animals. Melanogenesis is under complex regulatory control by multiple agents interacting through pathways activated by hormonal and receptor-dependent and -independent mechanisms. There are about 20 genes that are involved in the biochemical pathway of melanogenesis and its regulation, which include: tyrosinase, microphthalmia-associated transcription factor, melanocortin1 receptor, adenylate cyclase, protein kinase A. Human melanogenesis regulatory proteins such as MAPK1, CREB3, and CREBP, have binary interaction with the protein of herpesvirus, hepatitis C virus, Human immunodeficiency virus type 1, Simian virus 40, and Human adenovirus A and C. Melanin is a double-edged sword in host-pathogen interaction (e.g., human-bacteria and/or fungi interaction). The inducers of upregulation of melanogenesis include fluvoxamine, famotidine, terbutaline, heliotrine, sirolimus, dicoumarol, Prestwick-860, carbimazole, (-)-MK-801, rilmenidine, hydrastine hydrochloride, haloperidol, scopolamine N-oxide, raubasine, and dihydroergocristine. In melanogenesis, GSK3B, CSNK2A, MAPK1, MAPK3, MAPK14, ERK1, and HIPK2 were the major kinases, while RUNX1, GATA1, and REST, SUN12, and RCOR1 were the major transcription factors. This study has reviewed the melanogenesis pathway, its regulations as well as applications to viral infection. The antiviral activity of melanin and its complex in the presence of antibacterial and antifungal compounds should be investigated to further provide insight for biomedical, biotechnological, and pharmacological applications.