Open AccessDesign and Two New Indol-Steroid Derivatives to Evaluate their Theoretical Activity Against Protein Kinase 2 (CK2) Protein
Author(s) -
RosasNexticapa Marcela,
Lauro FigueroaValverde,
Francisco Díaz-Cedillo,
LópezRamos Maria,
Mukhina Maria,
Garcimarrero E. Alejandara,
Cauich-Carrillo Regina
Publication year - 2020
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac106.68106820
Subject(s) - docking (animal) , chemistry , steroid , surface protein , protein kinase a , combinatorial chemistry , biochemistry , biophysics , kinase , biology , medicine , nursing , virology , hormone
Several compounds have been developed to evaluate their interaction with CK2-protein surface using some docking models. The objective of this investigation was to prepare two indol-steroid derivatives from 6-nitroprogesterone using some chemical strategies. In addition, the interaction of both compounds 3 and 6 with CK2-protein was evaluated in a docking model using quinalizarin as tool. The results showed that either compounds 3 or 6 have a higher affinity by 3FL9 protein surface compared with quinalizarin. In conclusion, this phenomenon suggests that either compounds 3 or 6 could exert changes in the biological activity of CK2 protein.