Open AccessSynthesis and Anticancer Activity of Novel Benzofurancarboxamides
Author(s) -
Yuliia Matiichuk,
Yu. V. Ostapiuk,
Taras Chaban,
Marta Sulyma,
Natalia Sukhodolska,
V. S. Matiychuk,
Ivan Franko
Publication year - 2020
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac106.65976609
Subject(s) - novelty , in vitro , cancer , cell culture , cancer cell lines , computational biology , combinatorial chemistry , chemistry , cancer cell , biochemistry , biology , psychology , genetics , social psychology
In our present work, we presented an efficient synthesis and anticancer activity evaluation of some novel benzofurancarboxamides. Our proposed approaches provide the possibility to design benzofurans diversity with a considerable chemical novelty. The synthesized substances were selected by the National Cancer Institute (NCI) Developmental Therapeutics Program for the in vitro cell line screening to investigate their anticancer activity. The compounds with significant levels of anticancer activities have been found that can be used for further optimization.