Open AccessSynthesis, anti-inflammatory activityand molecular docking of 2-methyl-3-furamides
Author(s) -
Yuliia Matiichuk,
В. В. Огурцов,
Yu. V. Ostapiuk,
Taras Chaban,
V. S. Matiychuk
Publication year - 2020
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac104.809814
Subject(s) - anti inflammatory , ibuprofen , chemistry , carrageenan , docking (animal) , drug , inflammation , proton nmr , combinatorial chemistry , pharmacology , stereochemistry , biochemistry , medicine , immunology , nursing
In an effort to develop novel anti-inflammatory agents, a series of novel 2-methyl-3-furamides were synthesized and modified.The structures of the obtained compounds were confirmed by 1H NMR spectroscopy and elemental analysis.The synthesized compounds were preselected via molecular docking to be tested for their anti-inflammatory activity. Researched substances impact effect on the inflammation exudative phase course was studied on the basis of white rats paws inflammatory edema carrageenan model. Anti-inflammatory activity researches have shown that synthesized compounds have possessed expressed anti-inflammatory properties, and some of them, in terms of activity, approach or exceed the comparison drug Ibuprofen.