Open AccessSynthesis antimicrobial and antitumor activities of 2-[5-(2-R-benzyl)thiazol-2-ylimino]thiazolidin-4-ones
Author(s) -
Іryna Drapak,
Volodymyr Foliush,
Taras Chaban,
V. S. Matiychuk
Publication year - 2020
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac103.507511
Subject(s) - antimicrobial , potassium thiocyanate , thiocyanate , chemistry , staphylococcus aureus , organic chemistry , bacteria , biology , genetics
By the reaction of N-(5-R-benzyl-thiazol-2-yl)-2-chloroacetamides with potassium thiocyanate were synthesized 2-[5-(2-R-benzyl)thiazol-2-ylimino]thiazolidin-4-ones. The structures of target compounds 9a-e were confirmed by using NMR spectroscopy and elemental analysis. The antimicrobial and anticancer activity of synthesized compounds was evaluated. The compounds with high antimicrobial activity against Staphylococcus aureus ATCC 43300 were identified.