Open AccessEffects of corticosteroids in patients with sickle cell disease and acute complications: a systematic review and meta-analysis
Author(s) -
Julien Lopinto,
Ségolène Gendreau,
Emilio Berti,
Pablo Bartolucci,
Anoosha Habibi,
Armand Mekontso Dessap
Publication year - 2022
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2021.280105
Subject(s) - medicine , randomized controlled trial , odds ratio , confidence interval , acute chest syndrome , meta analysis , retrospective cohort study , relative risk , blood transfusion , cohort study , cohort , surgery , disease , sickle cell anemia
Whether corticosteroids improve outcome in patients with acute complications of sickle cell disease (SCD) is still debated. We performed a systematic review of the literature with the aim of estimating effects of corticosteroids on the clinical course of vaso-occlusive crisis (VOC) or acute chest syndrome (ACS) in patients with SCD.The primary outcome was transfusion requirement during hospitalization. Studies were identified by search of MEDLINE and CENTRAL database. Three randomized clinical trials (RCT) and three retrospective cohort studies (RCS) were included, involving 3,304 participants and 5,562 VOC or ACS episodes.There was no difference between corticosteroids and standard treatment regarding transfusion overall [OR=0.98 (95% CI 0.38 to 2.53)], but with a significant interaction of study type (P