Open AccessClinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia
Author(s) -
Dimitrios Papaioannou,
Hatice Gülçin Özer,
Deedra Nicolet,
Amog P. Urs,
Tobias Herold,
Krzysztof Mrózek,
Aarif M.N. Batcha,
Klaus H. Metzeler,
Ayse Selen Yilmaz,
Stefano Volinia,
Marius Bill,
Jessica Kohlschmidt,
Maciej Pietrzak,
Christopher J. Walker,
Andrew J. Carroll,
Jan Braess,
Bayard L. Powell,
AnnKathrin Eisfeld,
Brian Uy,
Eunice S. Wang,
Jonathan E. Kolitz,
Richard Stone,
Wolfgang Hiddemann,
John C. Byrd,
Clara D. Bloomfield,
Ramiro Garzon
Publication year - 2021
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2021.266643
Subject(s) - biology , myeloid leukemia , transcriptome , clinical significance , long non coding rna , cytosine , gene , cancer research , rna , myeloid , leukemia , genetics , single nucleotide polymorphism , allele , gene expression , medicine , genotype
Expression levels of long non-coding RNAs (lncRNAs) have been shown to associate with clinical outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, the frequency and clinical significance of genetic variants in the nucleotide sequences of lncRNAs in AML patients is unknown. Herein, we analyzed total RNA sequencing data of 377 younger adults (aged