Open AccessGenetic variations in T-cell activation and effector pathways modulate alloimmune responses after allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies
Author(s) -
Haowen Xiao,
Yi Luo,
Xiaoyu Lai,
Shan Fu,
Jimin Shi,
Yamin Tan,
Jingsong He,
Wanzhuo Xie,
Weiyan Zheng,
Li Mengmeng Wang,
Lifei Zhang,
Lizhen Liu,
Xiujin Ye,
Xiaohong Yu,
Zhen Cai,
Maofang Lin,
He Huang
Publication year - 2012
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2012.066159
Subject(s) - cytotoxic t cell , immunology , transplantation , hematopoietic stem cell transplantation , granzyme b , genotype , stem cell , granzyme , biology , human leukocyte antigen , antigen , medicine , cd8 , perforin , gene , genetics , in vitro
Recently, several important polymorphisms have been identified in T-cell activation and effector pathway genes and have been reported to be associated with inter-patient variability in alloimmune responses. The present study was designed to assess the impact of these genetic variations on the outcomes of allogeneic hematopoietic stem cell transplantation.