Open AccessPredictors of osteoclast activity in patients with sickle cell disease
Author(s) -
Mehdi Nouraie,
Kevin Cheng,
Xiaomei Niu,
Evadne Moore-King,
Margaret F. Fadojutimi-Akinsi,
Caterina P. Minniti,
Craig Sable,
Sohail Rana,
Niti Dham,
Andrew Campbell,
Gregory Ensing,
Gregory J. Kato,
Mark T. Gladwin,
Oswaldo Castro,
Victor R. Gordeuk
Publication year - 2011
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2011.042499
Subject(s) - acid phosphatase , tartrate resistant acid phosphatase , medicine , endocrinology , sickle cell anemia , tartrate , osteoclast , alkaline phosphatase , immunology , chemistry , biochemistry , disease , enzyme , receptor
Bone changes are common in sickle cell disease, but the pathogenesis is not fully understood. Tartrate-resistant acid phosphatase (TRACP) type 5b is produced by bone-resorbing osteoclasts. In other forms of hemolytic anemia, increased iron stores are associated with osteoporosis. We hypothesized that transfusional iron overload would be associated with increased osteoclast activity in patients with sickle cell disease.