Open AccessExpression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia
Author(s) -
Diana Schotte,
Ellen Lange-Turenhout,
Dominique J.P.M. Stumpel,
Ronald W. Stam,
Jessica Buijs-Gladdines,
Jules P.P. Meijerink,
Rob Pieters,
Monique L. den Boer
Publication year - 2010
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2010.023481
Subject(s) - biology , microrna , cancer research , leukemia , gene , polymerase chain reaction , acute leukemia , microbiology and biotechnology , genetics
Deregulation of microRNA may contribute to hematopoietic malignancies. MicroRNA-196b (miR-196b) is highly expressed in MLL-rearranged leukemia and has been shown to be activated by MLL and MLL-fusion genes.