Open AccessLack of expression of inhibitory KIR3DL1 receptor in patients with natural killer cell-type lymphoproliferative disease of granular lymphocytes
Author(s) -
Cristina Gattazzo,
Antonella Teramo,
Marta Miorin,
Elisa Scquizzato,
Anna Cabrelle,
Mirna Balsamo,
Carlo Agostini,
Elena Vendrame,
Monica Facco,
Maria Paola Albergoni,
Livio Trentin,
Massimo Vitale,
Gianpietro Semenzato,
Renato Zambello
Publication year - 2010
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2010.023358
Subject(s) - receptor , dna methylation , biology , immunology , lymphoproliferative disorders , cd16 , methylation , population , natural killer cell , receptor expression , cd3 , gene expression , microbiology and biotechnology , gene , lymphoma , immune system , medicine , cytotoxic t cell , genetics , cd8 , environmental health , in vitro
Natural killer cell-type lymphoproliferative disease of granular lymphocytes is a disorder characterized by chronic proliferation of CD3(-)CD16(+) granular lymphocytes. By flow cytometry analysis, we previously demonstrated a dysregulation in killer immunoglobulin-like receptor (KIR) expression in natural killer cells from patients with this lymphoproliferative disease, the activating KIR receptors being mostly expressed. We also found that patients with natural killer cell-type lymphoproliferative disease of granular lymphocytes usually had KIR genotypes characterized by multiple activating KIR genes.