Open AccessHeme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter
Author(s) -
Samuele Marro,
Deborah Chiabrando,
Erika Messana,
Jens Stolte,
Emilia Turco,
Emanuela Tolosano,
Martina U. Muckenthaler
Publication year - 2010
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2009.020123
Subject(s) - ferroportin , heme , heme oxygenase , biochemistry , chemistry , transferrin , transcription factor , microbiology and biotechnology , biology , gene , iron homeostasis , enzyme
Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin. In the plasma, iron binds to transferrin and is made available for de novo red cell synthesis. The aim of this study was to gain insight into the regulatory mechanisms that control the transcriptional response of iron export protein ferroportin to hemoglobin in macrophages.