Open AccessCombining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation
Author(s) -
Kai Neben,
Anna Jauch,
Uta Bertsch,
Christian Heiß,
Thomas Hielscher,
Anja Seckinger,
Tina Mors,
Nadine Müller,
Jens Hillengaß,
Marc S. Raab,
Anthony Dick Ho,
Dirk Hose,
Hartmut Goldschmidt
Publication year - 2010
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2009.016436
Subject(s) - multiple myeloma , hazard ratio , fluorescence in situ hybridization , autologous stem cell transplantation , medicine , oncology , transplantation , multivariate analysis , cytogenetics , univariate , univariate analysis , stem cell , pathology , multivariate statistics , biology , gene , chromosome , confidence interval , genetics , statistics , mathematics
Chromosomal abnormalities have been shown to play a major role in disease evolution of multiple myeloma. Specific changes in interphase cells can be detected by fluorescent in situ hybridization, which overcomes the problem of the lack of dividing cells required for conventional cytogenetics.