Open AccessMyelin protein zero is naturally processed in the B cells of monoclonal gammopathy of undetermined significance of immunoglobulin M isotype: aberrant triggering of a patient's T cells
Author(s) -
Eva Hellqvist,
Maria Kvarnström,
Anita Söderberg,
Magnus Vrethem,
Jan Ernerudh,
Anders Rosén
Publication year - 2009
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2009.015123
Subject(s) - monoclonal gammopathy of undetermined significance , isotype , microbiology and biotechnology , monoclonal antibody , biology , antibody , antigen , t cell , monoclonal , immunology , immune system
Monoclonal gammopathy of undetermined significance of immunoglobulin M isotype is a condition with clonally expanded B cells, recently suggested to have an infectious origin. This monoclonal gammopathy is frequently associated with polyneuropathy and antibodies against myelin protein zero, whereas the role of the T cells remains largely unknown. We analyzed protein zero-specific B cells, as antigen-presenting cells, and their capacity to activate T helper cells.