Open AccessIncreased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma
Author(s) -
Christopher J. Stasik,
Hiroaki Nitta,
Wenjun Zhang,
Charles H. Mosher,
James R. Cook,
Raymond R. Tubbs,
Joseph M. Unger,
Tracy A. Brooks,
Daniel Persky,
Sarah T. Wilkinson,
Thomas M. Grogan,
Lisa M. Rimsza
Publication year - 2010
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2009.012864
Subject(s) - copy number variation , biology , gene dosage , polysomy , gene , gene expression , messenger rna , gene duplication , microbiology and biotechnology , diffuse large b cell lymphoma , chromosome , lymphoma , in situ hybridization , genetics , immunology , genome
Translocations involving the MYC gene and increased MYC mRNA levels are associated with poor outcome in diffuse large B-cell lymphoma. However, the presence of increased MYC gene copy number and/or polysomy of chromosome 8 have not been previously described.