Open AccessRho GTPase Cdc42 is essential for human T-cell development
Author(s) -
Kaatje Smits,
Veronica Iannucci,
Veronique Stove,
P. van Hauwe,
Evelien Naessens,
Pieter Meuwissen,
Kevin K. Ariën,
Mostafa Bentahir,
Jean Plum,
Bruno Verhasselt
Publication year - 2010
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2009.006890
Subject(s) - cdc42 , gtpase , rac1 , microbiology and biotechnology , rhoa , biology , thymocyte , cell migration , t cell , cell growth , cell , signal transduction , immunology , immune system , biochemistry
Rho GTPases are involved in the regulation of many cell functions, including some related to the actin cytoskeleton. Different Rho GTPases have been shown to be important for T-cell development in mice. However, their role in human T-cell development has not yet been explored.