Open AccessGenetic similarity of chromosome 6 between patients receiving hematopoietic stem cell transplantation and HLA matched sibling donors
Author(s) -
Hannu Turpeinen,
Liisa Volin,
Lauri Nikkinen,
Pauli J. Ojala,
Aarno Palotie,
Janna Saarela,
Jukka Partanen
Publication year - 2009
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2008.000919
Subject(s) - hematopoietic stem cell transplantation , biology , transplantation , human leukocyte antigen , genetics , sibling , stem cell , chromosome , single nucleotide polymorphism , immunology , gene , genotype , medicine , antigen , psychology , developmental psychology
Matching for HLA genes located on chromosome 6 is required in hematopoietic stem cell transplantation to reduce the incidence of graft-versus-host disease. However, a considerable proportion of patients still suffer from it, obviously due to genetic differences outside the HLA gene region.