Open AccessThe effect of FK506 on transforming growth factor signaling and apoptosis in chronic lymphocytic leukemia B cells
Author(s) -
Simona Romano,
Maria Mallardo,
Federico Chiurazzi,
Rita Bisogni,
Anna Dilhas,
Raffaele Liuzzi,
Giovanna Compare,
Maria Romano
Publication year - 2008
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.12402
Subject(s) - chronic lymphocytic leukemia , smad , apoptosis , biology , flow cytometry , cancer research , transforming growth factor , signal transduction , leukemia , programmed cell death , phosphorylation , microbiology and biotechnology , kinase , gene silencing , blot , immunology , biochemistry , gene
Loss of response to transforming growth factor-beta (TGF-beta ) is thought to contribute to the progression of chronic lymphocytic leukemia. Recent findings of over-activation of the TGF-beta signal in FKBP12-knockout mouse prompted us to investigate whether FK506, the canonical ligand of FKBP, can activate the TGF-beta signal in chronic lymphocytic leukemia.