Open AccessAtrial dysfunction as a marker of iron cardiotoxicity in thalassemia major
Author(s) -
Walter Li,
Thomas D. Coates,
John C. Wood
Publication year - 2008
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.11958
Subject(s) - cardiology , medicine , ejection fraction , cardiotoxicity , thalassemia , cardiac function curve , peripheral , heart failure , chemotherapy
We measured left atrial size and function from biplane MRI data in 62 adults with thalassemia major. Age-adjusted left atrial ejection fraction was depressed in 7 out of 20 subjects having T2* < 10 ms. Left atrial size, left ventricular size and cardiac output fell with cardiac iron loading, representing increased cardiac or peripheral vascular stiffness.