Open AccessInterferon induces a good molecular response in a patient with chronic eosinophilic leukemia (CEL) carrying the JAK2V617F point mutation
Author(s) -
Grzegorz Helbig,
Beata StellaHołowiecka,
Mirosław Majewski,
Monika Lewandowska,
Jerzy Hołowiecki
Publication year - 2007
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.11841
Subject(s) - eosinophilic , clone (java method) , hypereosinophilic syndrome , medicine , leukemia , mutation , point mutation , immunology , interferon , hematology , chronic leukemia , eosinophilia , cancer research , biology , acute leukemia , pathology , dna , gene , genetics
The JAK2 V617F point mutation is very rare in hypereosinophilic syndrome and/or chronic eosinophilic leukemia. Here we report on a patient with chronic eosinophilic leukemia and detectable JAK2 mutant clone, who achieved a good molecular response to interferon alpha-2a after 4 months of treatment. The molecular response correlated with only moderate haematological improvement.