Open AccessPrognostic factors in monoclonal gammopathy of undetermined significance
Author(s) -
Federico Sackmann,
Miguel Arturo Pavlovsky,
Claudia Corrado,
Marco Pizzolato,
Mariel Emilce Alejandre,
Santiago Pavlovsky
Publication year - 2008
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.11744
Subject(s) - monoclonal gammopathy of undetermined significance , medicine , monoclonal gammopathy , retrospective cohort study , progression free survival , overall survival , monoclonal antibody , clinical significance , monoclonal , statistical significance , gastroenterology , oncology , antibody , immunology
A retrospective evaluation of 285 patients with monoclonal gammopathy of undetermined significance was performed to identify variables associated with progression, actuarial progression free survival (PFS) and overall survival (OS). Three variables, level of uninvolved immunoglobulins (HR 4.98, CI95% 2 -12.4, p=0.0006), monoclonal protein concentration (HR 4.04, CI95% 1.6-10.34, p=0.004), and erythrosedimentation rate (HR 3.94, CI95% 1.33-11.6, p=0.01), showed independent prognostic significance. With a median follow-up of 66 months (range 6-378), PFS and OS at 10 years were 89% and 91% respectively.