Open AccessRepeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study
Author(s) -
Martino Introna,
Gianmaria Borleri,
Elena Conti,
Marta Franceschetti,
Anna Maria Barbui,
Raewyn Broady,
Erica Dander,
Giuseppe Gaipa,
Giovanna D’Amico,
Ettore Biagi,
Matteo Parma,
Enrico Maria Pogliani,
Orietta Spinelli,
D Baronciani,
Anna Grassi,
Josée Golay,
Tiziano Barbui,
Andrea Biondi,
Alessandro Rambaldi
Publication year - 2007
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.11132
Subject(s) - medicine , transplantation , hematopoietic stem cell transplantation , leukemia , stem cell , chemotherapy , immunology , gastroenterology , haematopoiesis , chronic myelomonocytic leukemia , cytokine , graft versus host disease , oncology , myelodysplastic syndromes , bone marrow , biology , genetics
Cytokine-induced killer (CIK) cells have shown anti-leukemic activity and little graft-versus-host disease (GVHD) in several animal models. The safety of these cells in autologous settings has been shown. We performed a phase I study of allogeneic (donor's) CIK cells in patients relapsing after allogeneic haematopoietic stem cell transplantation (HSCT).