Predictive factors and impact of full donor T-cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation | Zendy

Mohamad Mohty | Zendy; O. Avinens | Zendy; C. Faucher | Zendy; Patrice Viens | Zendy; Didier Blaise | Zendy; J.-F. Eliaou | Zendy

Open Access

Predictive factors and impact of full donor T-cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation

Author(s) -

Mohamad Mohty,

O. Avinens,

C. Faucher,

Patrice Viens,

Didier Blaise,

J.-F. Eliaou

Publication year - 2007

Publication title -

haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.782

H-Index - 142

eISSN - 1592-8721

pISSN - 0390-6078

DOI - 10.3324/haematol.10971

Subject(s) - cumulative incidence , medicine , incidence (geometry) , transplantation , stem cell , immunology , transplantation chimera , hematopoietic stem cell transplantation , gastroenterology , oncology , hematopoietic cell , haematopoiesis , biology , physics , optics , genetics

This study investigated the kinetics of CD3+-T cell chimerism (TCC) in 102 patients receiving reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) from an HLA-identical sibling. Patients with full donor TCC at day 30 had a higher incidence of grade 2-4 acute GVHD compared to patients in mixed TCC (cumulative-incidence, 61% vs. 35%; p=0.01). The delayed establishment of full donor TCC in myeloid malignancies was associated with a higher incidence of relapse (40% vs. 0; p=0.002), suggesting that monitoring of the kinetics of TCC is mandatory after RIC-allo-SCT.

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