Open AccessPredictive factors and impact of full donor T-cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation
Author(s) -
Mohamad Mohty,
Odile Avinens,
Catherine Faucher,
Patrice Viens,
Didier Blaise,
JeanFrançois Eliaou
Publication year - 2007
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.10971
Subject(s) - cumulative incidence , medicine , incidence (geometry) , transplantation , stem cell , immunology , transplantation chimera , hematopoietic stem cell transplantation , gastroenterology , oncology , hematopoietic cell , haematopoiesis , biology , physics , optics , genetics
This study investigated the kinetics of CD3+-T cell chimerism (TCC) in 102 patients receiving reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) from an HLA-identical sibling. Patients with full donor TCC at day 30 had a higher incidence of grade 2-4 acute GVHD compared to patients in mixed TCC (cumulative-incidence, 61% vs. 35%; p=0.01). The delayed establishment of full donor TCC in myeloid malignancies was associated with a higher incidence of relapse (40% vs. 0; p=0.002), suggesting that monitoring of the kinetics of TCC is mandatory after RIC-allo-SCT.