Open AccessAnti-erythroblast autoimmunity in early myelodysplastic syndromes
Author(s) -
Wilma Barcellini,
Anna Zanii,
Francesca Guia Imperiali,
Carla Boschetti,
M. Colombi,
Alessandra Iurlo,
Alberto Zanella
Publication year - 2007
Publication title -
haematologica
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.10546
Subject(s) - autoimmunity , immunology , autoantibody , bone marrow , erythroblast , medicine , cytokine , myelodysplastic syndromes , autoimmune hemolytic anemia , tumor necrosis factor alpha , fas ligand , apoptosis , anemia , biology , antibody , erythropoiesis , programmed cell death , biochemistry
Autoimmune phenomena, mainly directed against red blood cells are described in myelodysplastic syndromes (MDS), particularly early MDS, i.e. refractory anemia (RA) and RA with ringed sideroblasts (RARS). Dysregulation of apoptosis and immunoregulatory cytokines are thought to play a role in the pathogenesis of MDS.