Open AccessB-, T-, and NK-cell lineage involvement in JAK2V617F-positive patients with idiopathic myelofibrosis
Author(s) -
Costanza Bogani,
Paola Guglielmelli,
Elisabetta Antonioli,
Alessandro Pancrazzi,
Alberto Bosi,
Alessandro M. Vannucchi
Publication year - 2007
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.10527
Subject(s) - myelofibrosis , jak2 v617f , myeloid , lineage (genetic) , mutation , progenitor cell , immunology , medicine , biology , cancer research , stem cell , bone marrow , gene , genetics
An acquired JAK2 (V617F)mutation has been found in myeloid cells from most patients with chronic idiopathic myelofibrosis (IM), but whether it occurs in a common myelo-lymphoid, rather than a myeloid-restricted, progenitor cell is still debated. Using a sensitive ARMS assay for the quantitative assessment of JAK2 (V617F)cDNA, we detected the mutation in purified B-, T- and NK-cells from about half of 12 patients studied. These results indicate that involvement of lymphoid lineage in IM may be more frequent than previously supposed.