Open AccessIntegrative genomic analysis reveals distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma
Author(s) -
Luca Agnelli,
Silvio Bicciato,
Sonia Fabris,
Luca Baldini,
Fortunato Morabito,
Daniela Intini,
Donata Verdelli,
Andrea Callegaro,
Francesco Bertoni,
Giorgio Lambertenghi-Deliliers,
Luigia Lombardi,
Antonino Neri
Publication year - 2007
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.10414
Subject(s) - biology , fluorescence in situ hybridization , genetics , gene , chromosome , chromosome 21 , chromosomal translocation , trisomy , chromosome 7 (human) , microbiology and biotechnology , chromosome 18 , chromosome 13 , gene expression profiling , gene expression
The chromosome 13 deletion (Delta13) is one of the most frequent chromosomal alterations in multiple myeloma (MM). Delta13 is associated with an unfavorable prognosis, although there is increasing agreement that its prognostic relevance must be related to the ploidy status and the presence of different chromosomal translocations. The aim of this study was to provide a comprehensive analysis of the transcriptional features of Delta13 in MM.