Open AccessThe use of bone marrow and peripheral blood stem cell transplantation in the treatment of cancer
Author(s) -
Appelbaum Frederick R.
Publication year - 1996
Publication title -
ca: a cancer journal for clinicians
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 62.937
H-Index - 168
eISSN - 1542-4863
pISSN - 0007-9235
DOI - 10.3322/canjclin.46.3.142
Subject(s) - transplantation , bone marrow , medicine , chemoradiotherapy , haematopoiesis , stem cell , leukemia , total body irradiation , cancer , chemotherapy , immunology , surgery , biology , cyclophosphamide , genetics
Since its first successful application 25 years ago, the clinical use of bone marrow and peripheral blood stem cell transplantation has increased dramatically. Transplantation allows for the administration of high doses of systematic chemotherapy and radiotherapy and confers an antitumor effect separate from the effects of chemotherapy. However,complications including toxicity of treatment, graft failure, and graft-versus-host disease exist. This article reviews the history and current use of bone marrow and peripheral blood stem cell transplantation and outlines new approaches for clinical application.