Open AccessAn interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma
Author(s) -
Hasanov Elshad,
Yeboa Debra Nana,
Tucker Mathew D.,
Swanson Todd A.,
Beckham Thomas Hendrix,
Rini Brian,
Ene Chibawanye I.,
Hasanov Merve,
Derks Sophie,
Smits Marion,
Dudani Shaan,
Heng Daniel Y. C.,
Brastianos Priscilla K.,
Bex Axel,
Hanalioglu Sahin,
Weinberg Jeffrey S.,
Hirsch Laure,
Carlo Maria I.,
Aizer Ayal,
Brown Paul David,
Bilen Mehmet Asim,
Chang Eric Lin,
Jaboin Jerry,
Brugarolas James,
Choueiri Toni K.,
Atkins Michael B.,
McGregor Bradley A.,
Halasz Lia M.,
Patel Toral R.,
Soltys Scott G.,
McDermott David F.,
Elder James Bradley,
Baskaya Mustafa K.,
Yu James B.,
Timmerman Robert,
Kim Michelle Miran,
Mut Melike,
Markert James,
Beal Kathryn,
Tannir Nizar M.,
Samandouras George,
Lang Frederick F.,
Giles Rachel,
Jonasch Eric
Publication year - 2022
Publication title -
ca: a cancer journal for clinicians
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 62.937
H-Index - 168
eISSN - 1542-4863
pISSN - 0007-9235
DOI - 10.3322/caac.21729
Subject(s) - renal cell carcinoma , medicine , intensive care medicine , radiation therapy , kidney cancer , brain metastasis , metastasis , cancer , oncology
Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. CA Cancer J Clin. 2022;72:454‐489.