Open AccessCirculating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Author(s) -
Cheng Michael L.,
Pectasides Eirini,
Hanna Glenn J.,
Parsons Heather A.,
Choudhury Atish D.,
Oxnard Geoffrey R.
Publication year - 2020
Publication title -
ca: a cancer journal for clinicians
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 62.937
H-Index - 168
eISSN - 1542-4863
pISSN - 0007-9235
DOI - 10.3322/caac.21650
Subject(s) - circulating tumor dna , precision oncology , medicine , patient care , clinical practice , solid tumor , clinical oncology , oncology , bioinformatics , intensive care medicine , cancer , biology , family medicine , nursing
The application of genomic profiling assays using plasma circulating tumor DNA (ctDNA) is rapidly evolving in the management of patients with advanced solid tumors. Diverse plasma ctDNA technologies in both commercial and academic laboratories are in routine or emerging use. The increasing integration of such testing to inform treatment decision making by oncology clinicians has complexities and challenges but holds significant potential to substantially improve patient outcomes. In this review, the authors discuss the current role of plasma ctDNA assays in oncology care and provide an overview of ongoing research that may inform real‐world clinical applications in the near future.