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Germline mutations in pancreatic cancer become better defined
Author(s) -
Barton Mary Kay
Publication year - 2016
Publication title -
ca: a cancer journal for clinicians
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 62.937
H-Index - 168
eISSN - 1542-4863
pISSN - 0007-9235
DOI - 10.3322/caac.21300
Subject(s) - germline , genetic counseling , genetic testing , germline mutation , pancreatic cancer , genetics , family history , medicine , mutation , oncology , cancer , biology , bioinformatics , gene
Key Points Germline mutations occur in approximately 15% of patients with PAC. These 2 studies suggest that genetic counseling and testing are appropriate for patients with early‐onset PAC or a family history of PAC, those with one of several associated cancers, and those of Ashkenazi Jewish ancestry. Further study and guidelines are needed to integrate genetic testing for PAC into practice.

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