Open AccessOral cavity and oropharyngeal squamous cell carcinoma—an update
Author(s) -
Chi Angela C.,
Day Terry A.,
Neville Brad W.
Publication year - 2015
Publication title -
ca: a cancer journal for clinicians
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 62.937
H-Index - 168
eISSN - 1542-4863
pISSN - 0007-9235
DOI - 10.3322/caac.21293
Subject(s) - medicine , malignancy , basal cell , head and neck , incidence (geometry) , head and neck cancer , epidemiology , oral cavity , dermatology , cancer , oncology , human papillomavirus , carcinoma , radiology , pathology , surgery , dentistry , physics , optics
Answer questions and earn CME/CNE Oral cavity squamous cell carcinoma (OC‐SCC) is the most common malignancy of the head and neck (excluding nonmelanoma skin cancer). Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma (OP‐SCC), with a marked increase in lesions related to human papillomavirus infection. This update presents the latest evidence regarding OC‐SCC and OP‐SCC. In particular, the authors compare and contrast tumors at these two sites with respect to epidemiology, etiopathogenesis, clinicopathologic presentation, clinical assessment, imaging, management, and prognosis. It is important for clinicians to be aware of differences between OC‐SCC and OP‐SCC so that appropriate patient education and multidisciplinary care can be provided to optimize outcomes. CA Cancer J Clin 2015;65:401–421 . © 2015 American Cancer Society .