Open AccessImproving the outcome for children with cancer: Development of targeted new agents
Author(s) -
Adamson Peter C.
Publication year - 2015
Publication title -
ca: a cancer journal for clinicians
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 62.937
H-Index - 168
eISSN - 1542-4863
pISSN - 0007-9235
DOI - 10.3322/caac.21273
Subject(s) - medicine , cancer , pediatric cancer , adverse effect , disease , drug development , imatinib mesylate , pediatrics , oncology , intensive care medicine , imatinib , drug , pharmacology , myeloid leukemia
The outcome for children with cancer has improved significantly over the past 60 years, with greater than 80% of patients today becoming 5‐year survivors. Despite this progress, cancer remains the leading cause of death from disease in children in the United States, and significant short‐term and long‐term treatment toxicities continue to impact the majority of children with cancer. The development of targeted new agents offers the prospect of potentially more effective and less toxic treatment for children. More than a decade since imatinib mesylate was introduced into the treatment of children with Philadelphia chromosome‐positive acute lymphoblastic leukemia, transforming its outcome, a range of targeted agents has undergone study in pediatric cancer patients. Early lessons learned from these studies include a better understanding of the adverse event profile of these drugs in children, the challenge of developing pediatric‐specific formulations, and the continued reliance on successful development for adult cancer indications on pediatric drug development. The collaborative research infrastructure for children with cancer in the United States is well positioned to advance novel treatments into clinical investigations for a spectrum of rare and ultra‐rare childhood cancers. A greater investment of resources in target discovery and validation can help drive much needed development of new, more effective treatments for children with cancer. CA Cancer J Clin 2015;65: 212–220. © 2015 American Cancer Society.