Open AccessFactors Predicting Survival in Ruptured Hepatocellular Carcinoma Treated with Surgical Resection
Author(s) -
Charnwit Assawasirisin,
Pholasith Sangserestid,
Yongyut Sirivatanauksorn,
Somchai Limsrichamrern,
Prawat Kositamongkol,
Prawej Mahawithitwong,
Chutwichai Tovikkai,
Wethit Dumronggittigule
Publication year - 2022
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 2
ISSN - 2629-995X
DOI - 10.33192/smj.2022.6
Subject(s) - medicine , hepatocellular carcinoma , hepatectomy , surgery , retrospective cohort study , resection , resection margin , overall survival , carcinoma , surgical margin
Background: Today, ruptured hepatocellular carcinoma (HCC) is a less frequently encountered problem globally due to availability of cancer surveillance protocols for the high-risk population. However, in Thailand, a number of patients do not enroll in screening programs, leading to high rates of ruptured complications. In fit-for-surgery and clinically stable patients, hepatectomy means long-term survival. This study aimed to identify predictive factors of survival in resected patients.
Methods: A retrospective review of patients with ruptured HCC who underwent liver resection between January 2013 and December 2019 at Siriraj Hospital was performed. The clinical data and outcomes of patients were analyzed.
Results: A total of forty-five patients with ruptured HCC underwent resection or 9.8% (45/460) of all operable HCC cases. There were 6 patients (14.3%) who suffered from postoperative liver failure and one patient (2.4%) died within 30 days. Overall survival (OS) and recurrence-free survival were 90%, 64%, 52% and 42.5%, 24%, 16% at 1, 3, and 5 years, respectively. The factors affecting OS were tumor size > 10 cm, vascular invasion, and positive resection margin.
Conclusion: Ruptured HCC is treatable disease and surgical resection plays a major role in good outcomes in patients.