Aldosterone and cardiovascular remodelling: focus on myocardial failure | Zendy

Frederick K. Shieh | Zendy; Eugene Kotlyar | Zendy; Flora Sam | Zendy

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Aldosterone and cardiovascular remodelling: focus on myocardial failure

Author(s) -

Frederick K. Shieh,

Eugene Kotlyar,

Flora Sam

Publication year - 2004

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.3317/jraas.2004.005

Subject(s) - eplerenone , heart failure , cardiology , aldosterone , medicine , neurohormones , myocardial infarction , spironolactone , hormone

Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival trial have emphasised the clinical importance of aldosterone. This review addresses some of the proposed mechanisms of LV remodelling in heart failure.

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