Renal graft failure after addition of an angiotensin II receptor antagonist to an angiotensin-converting enzyme inhibitor: unmasking of an unknown iliac artery stenosis | Zendy

AnneLise Kamper | Zendy; Arne Høj Nielsen | Zendy; Niels Bækgaard | Zendy; Svend Just | Zendy

Open Access

Renal graft failure after addition of an angiotensin II receptor antagonist to an angiotensin-converting enzyme inhibitor: unmasking of an unknown iliac artery stenosis

Author(s) -

AnneLise Kamper,

Arne Høj Nielsen,

Niels Bækgaard,

Svend Just

Publication year - 2002

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.3317/jraas.2002.016

Subject(s) - renal artery stenosis , medicine , renin–angiotensin system , angiotensin receptor , angiotensin converting enzyme , ace inhibitor , angiotensin ii receptor type 1 , angiotensin ii , renal artery , renal artery obstruction , cardiology , endocrinology , pharmacology , urology , receptor , kidney , blood pressure

Combined treatment with an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II (Ang II) receptor blocker (ARB) has been suggested in order to achieve a more complete blockade of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. The present report describes a case of acute renal graft dysfunction following the addition of an ARB to existing ACE inhibition. This unmasked an unknown iliac artery stenosis. The case indicates a possible important role of Ang II generated by non-ACE pathways in this situation.

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