Open AccessInteraction of ACE inhibitors and AT1-receptor blockers on maximum blood pressure response in spontaneous hypertensive rats
Author(s) -
Trefor Morgan,
Cory D. Griffiths,
L. Delbridge
Publication year - 2002
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.3317/jraas.2002.002
Subject(s) - losartan , captopril , medicine , blood pressure , angiotensin converting enzyme , pharmacology , ace inhibitor , drug , angiotensin ii receptor type 1 , angiotensin ii , endocrinology
This study in spontaneous hypertensive rats (SHR) was designed to determine whether a greater fall in blood pressure (BP) could be achieved with the combination of an angiotensin-converting enzyme inhibitor (ACE-I) and an AT 1 -receptor blocking drug than with higher doses of either drug alone. The peak effect of captopril occurred 3—4 hours post-dose and a plateau response was achieved with 10 mg/kg. The peak effect of losartan occurred 7—8 hours post-dose and a plateau response was achieved with 10 mg/kg. Increasing the dose of either drug caused no greater fall in BP, but increased the duration of the effect. Captopril, 10 mg/kg, administered with losartan 10 mg/kg caused a greater fall in BP than captopril or losartan, 20 mg/kg. This was present after acute doses or after one week of daily therapy. The combination of ACE-I and AT 1 -blocking drugs is more effective than either therapy alone and may be a useful combination to manage hypertension and/or cardiac failure.