Insights derived from ACE knockout mice | Zendy

Justin M. Cole | Zendy; Dilek Ertoy | Zendy; Kenneth E. Bernstein | Zendy

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Insights derived from ACE knockout mice

Author(s) -

Justin M. Cole,

Dilek Ertoy,

Kenneth E. Bernstein

Publication year - 2000

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.3317/jraas.2000.016

Subject(s) - blood pressure , knockout mouse , homeostasis , kidney , renal function , endocrinology , medicine , biology , physiology , receptor

The evaluation of ACE knockout mice has illustrated the tremendous physiologic importance of the RAAS. We have discussed how interruption of this system influences blood pressure, renal function, renal development, serum and urine electrolyte composition, haematocrit and male reproductive capacity. This body of data underlines the modelling of the RAAS as a type of biological machine that is positioned to respond to environmental insult and to maintain a homeostasis of blood pressure, blood volume and electrolyte composition. These data also emphasise Harry Goldblatt's seminal observation that the kidney and the RAAS are intimately linked in the regulation of normal blood pressure.

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