Rat model for investigating ACTH-independent angiotensin-induced aldosterone secretion | Zendy

Darren M. Roesch | Zendy; Ying Tian | Zendy; Joseph G. Verbalis | Zendy; Kathryn Sandberg | Zendy

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Rat model for investigating ACTH-independent angiotensin-induced aldosterone secretion

Author(s) -

Darren M. Roesch,

Ying Tian,

Joseph G. Verbalis,

Kathryn Sandberg

Publication year - 2000

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.3317/jraas.2000.008

Subject(s) - aldosterone , medicine , endocrinology , adrenocorticotropic hormone , secretion , angiotensin ii , stimulation , renin–angiotensin system , hormone , adrenal cortex , dexamethasone , acth secretion , chemistry , receptor , blood pressure

Study of the acute effects of angiotensin II (Ang II) on aldosterone secretion has been hindered by the confounding influence of Ang II-induced adrenocorticotropic hormone (ACTH) secretion on aldosterone secretion, and by the fact that when laboratory rats are fed standard laboratory chows that are high in sodium, the adrenal is only minimally responsive to Ang II. In this study, we report the development of a model of Ang II-induced aldosterone secretion in NaCl-deprived, dexamethasone (DEX)-treated rats. This model allows the observation of (a) a high magnitude of Ang II-induced aldosterone secretion, (b) a return of plasma aldosterone levels to baseline after stimulation, and (c) aldosterone secretion without the potentially confounding influence of ACTH stimulation.

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