Open AccessDisease-free Probability and Triple-Negative Breast Cancer
Author(s) -
Prakasit Chirappapha,
Thongchai Sukarayothin,
Yodying Wasuthit,
Ronnarat Suvikapalornkul,
Panuwat Lertsithichai,
Youwanush Kongdan
Publication year - 2012
Publication title -
ramathibodi medical journal
Language(s) - English
Resource type - Journals
ISSN - 2651-0561
DOI - 10.33165/rmj.2012.35.1.117663
Subject(s) - triple negative breast cancer , medicine , breast cancer , estrogen receptor , oncology , progesterone receptor , pathological , cancer , distant metastasis , triple negative , metastasis , stage (stratigraphy) , disease , biology , paleontology
Objective: To compare the probabilities of local recurrence and distant metastasis between women with triple-negative and non- triple negative breast cancers.
Methods: Medical and pathological records of breast cancer patients treated between the years 2002 and 2006 were reviewed.
Results: There were 256 patients with complete data on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) expression determinations. There were 54 patients (21%) with triple-negative (ER-, PR-, HER2 -) cancers. Triple-negative patients were more likely to have larger tumors with higher histologic grade. The median fallow-up time was 4 years. The probabilities of local and distant recurrence were similar between the two groups of patients. Only two factors were independently and significantly associated with overall recurrence: tumor stage and tumor size.
Conclusion: Triple-negative breast cancer did not have a higher risk for both local recurrence and distant metastasis when compared with non-triple negative cancer.