Open AccessSubstantiation of using the ursodeoxycholic acid in the treatment of non-alcoholic steatohepatitis
Author(s) -
Н. Б. Губергріц,
N. V. Byelyayeva,
Г. М. Лукашевич,
П. Г. Фоменко,
A. V. Yuryeva
Publication year - 2019
Publication title -
vestnik kluba pankreatologov
Language(s) - English
Resource type - Journals
ISSN - 2077-5067
DOI - 10.33149/vkp.2019.01.11
Subject(s) - ursodeoxycholic acid , steatohepatitis , medicine , hepatocellular carcinoma , gastroenterology , alcoholic liver disease , fatty liver , disease , cirrhosis
The article provides brief epidemiological data on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, emphasizing the danger of steatohepatitis, progression of which may cause the development of hepatocellular carcinoma. The properties of ursodeoxycholic acid, which are the basis for its use in a treatment of non-alcoholic steatohepatitis, are analyzed in detail, such as cytoprotective, antioxidant, antifibrotic ones, effects on apoptosis, etc. The authors presented the results of the main evidence-based studies demonstrating the effectiveness of ursodeoxycholic acid and its combinations with other drugs in the treatment of non-alcoholic steatohepatitis.