Substantiation of using the ursodeoxycholic acid in the treatment of non-alcoholic steatohepatitis | Zendy

N. B. Gubergrits | Zendy; N. V. Byelyayeva | Zendy; Г. М. Лукашевич | Zendy; П. Г. Фоменко | Zendy; A. V. Yuryevа | Zendy

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Substantiation of using the ursodeoxycholic acid in the treatment of non-alcoholic steatohepatitis

Author(s) -

N. B. Gubergrits,

N. V. Byelyayeva,

Г. М. Лукашевич,

П. Г. Фоменко,

A. V. Yuryevа

Publication year - 2019

Publication title -

herald of pancreatic club

Language(s) - English

Resource type - Journals

ISSN - 2077-5067

DOI - 10.33149/vkp.2019.01.11

Subject(s) - ursodeoxycholic acid , steatohepatitis , medicine , hepatocellular carcinoma , gastroenterology , alcoholic liver disease , fatty liver , disease , cirrhosis

The article provides brief epidemiological data on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, emphasizing the danger of steatohepatitis, progression of which may cause the development of hepatocellular carcinoma. The properties of ursodeoxycholic acid, which are the basis for its use in a treatment of non-alcoholic steatohepatitis, are analyzed in detail, such as cytoprotective, antioxidant, antifibrotic ones, effects on apoptosis, etc. The authors presented the results of the main evidence-based studies demonstrating the effectiveness of ursodeoxycholic acid and its combinations with other drugs in the treatment of non-alcoholic steatohepatitis.

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