Open AccessStem mesenchymal bone marrow cells in the treatment of ulcerative colitis based on morphological and immunological research (literature review)
Author(s) -
В. С. Рахметова,
Aigul Orazbayeva,
A. Y. Amrenova
Publication year - 2018
Publication title -
vestnik kluba pankreatologov
Language(s) - English
Resource type - Journals
ISSN - 2077-5067
DOI - 10.33149/vkp.2018.01.09
Subject(s) - mesenchymal stem cell , ulcerative colitis , medicine , inflammatory bowel disease , bone marrow , stem cell , regeneration (biology) , immunology , stromal cell , colitis , disease , cancer research , pathology , biology , microbiology and biotechnology , genetics
The use of stem cells in complex therapy of inflammatory bowel diseases has became perspective therapeutic strategy. Mesenchymal stem cells, which have immunomodulatory, anti-inflammatory properties and high regenerative potential, are used for therapy of inflammatory bowel disease, what is making them attractive to clinical application. According to the results of the conducted studies, mesenchymal stem cells improve clinical and microscopic manifestations of colitis, reduce system and local production of pro-inflammatory cytokines, suppress inflammatory process, stimulating tissue regeneration at the same time, promote the increase in the duration of remission of a disease, reduce the risk of the relapse of ulcerative colitis. Preliminary results of clinical and experimental studies carried out in the world justify the relevance, prospects and sufficient safety of the transplantation method of allogenic mesenchymal stromal cells of bone marrow for treatment of patients with the ulcerative colitis.