Open AccessHemostasis disturbances in patients with acute pancreatitis and the ways of their correction
Author(s) -
С.М. Чуклін,
B. Ya. Pidhirnyi,
S.S. Chuklin
Publication year - 2017
Publication title -
vestnik kluba pankreatologov
Language(s) - English
Resource type - Journals
ISSN - 2077-5067
DOI - 10.33149/vkp.2017.02.02
Subject(s) - acute pancreatitis , hemostasis , medicine , pancreatitis , coagulation , coagulation cascade , disease , intensive care medicine , disseminated intravascular coagulation , inflammation , gastroenterology , platelet , thrombin
The literature review imposed the experimental and clinical data on the changes in the hemostatic system at acute pancreatitis. The reasons of hemostatic disorders and possible ways of its correction were identified. Disturbance in the coagulation is a feature at acute pancreatitis and is associated with disease severity. The results of experimental studies in animals and clinical studies suggest that modulation of hemostasis can provide a therapeutic target for the treatment of this disease. Inhibition of the coagulation cascade can prevent intravascular coagulation and inflammation in the pancreas and distant organs, thereby preventing systemic complications in patients with acute pancreatitis.