Open AccessHistostructure of pancreas in patients with autoimmune pancreatitis type I and II: connection with the level of IgG4-positive plasma cells
Author(s) -
Yu.A. Gaydar,
N.Yu. Oshmianska,
A. P. Halenko
Publication year - 2017
Publication title -
vestnik kluba pankreatologov
Language(s) - English
Resource type - Journals
ISSN - 2077-5067
DOI - 10.33149/vkp.2017.01.05
Subject(s) - autoimmune pancreatitis , pancreatitis , pancreas , medicine , autoimmune disease , pathology , immunohistochemistry , pathogenesis , fibrosis , differential diagnosis , pancreatic disease , disease
Differential diagnosis of autoimmune pancreatitis apart from everything else is based on specifics of immunoglobulin G4 involvement into the pathogenesis.
Aim is to analyze two forms of autoimmune pancreatitis and their relation to the level of IgG4-positive plasma cells.
Methods and results. The present study was conducted on 54 patients with chronic pancreatitis, from which 15 cases with autoimmune pancreatitis were selected by using morphological and immunohistochemical methods.
Conclusion. It has been established that for autoimmune pancreatitis type I dense lymphocytic periductal infiltrate, multilevel fibrosis, obliterating venulitis and high IgG4-positive plasma cells in the pancreas (>30 per high power field) were typical. In the cases of autoimmune pancreatitis type II, besides the specific histopathological signs of AIP, significantly epithelial damage of pancreatic ducts by leukocytes, low levels of IgG4-PPC in the pancreas and focal lesions on stages I–III of disease (80%) were observed.