Effect of Dietary Intake of Supplement Fertylor15 Containing Astaxanthin and Other Compounds on Human Sperm: In Vivo and In Vitro Study

Chronic stress and endocrine disorders that result from environmental pollution, reactive oxygen species (ROS), andgenetic abnormalities, are responsible of the idiopathic infertility. The aim of this study was to investigate the effect ofa daily intake of supplement containing astaxanthin (Asta), known to ameliorate sperm viability in in vitro conditions,and other elements, on semen quality. Sperm from 34 volunteers were analyzed before (T0) and after (T1) 30 daysof intake of supplement containing Asta, zinc, selenium, arginine, vitamins C and E, Coenzyme Q10 and folic acid.Semen parameters (sperm concentration, motility, morphology) and biochemical properties (rafts shifting, tyrosinephosphorylation (Tyr-P) and acrosome reaction (AR)) were evaluated. In additional 18 volunteers, Asta, all othercomponents or both were analyzed also in in vitro conditions. Results show an improvement of sperm quality witha decrease of membrane-bound IgG. The percentages of cells achieving capacitation and AR were increased (28±8to 52±10%, p<0.0001, and 24±5 to 46±7%, p<0.0001, respectively). The in vitro study assessed that Asta and othercompounds had a synergistic positive effect on all the biochemical parameters, with no sperm DNA fragmentation. Inconclusion, this dietary intake would be helpful in the treatment of no-complicated idiopathic infertility.