Open AccessThe Role of Cardiomyocyte Apoptosis in the Pathogenesis of Neuroleptic Cardiomyopathy
Publication year - 2019
Publication title -
medical and clinical research
Language(s) - English
Resource type - Journals
ISSN - 2577-8005
DOI - 10.33140/mcr.04.09.02
Subject(s) - pathogenesis , heart failure , cardiomyopathy , medicine , apoptosis , cardiology , biology , genetics
In the presented mini-review of the literature the role of cardiomyocyte apoptosis in the pathogenesis of neuroleptic cardiomyopathyis considered. Despite the insufficient development of the issue and the scarcity of literature data, various ways of negativeinfluence on the heart of the side effect of cardiotoxic antipsychotic drugs leading to a decrease in myocardial mass due to thedeath of cardiomyocytes by apoptosis are convincingly shown, which initiates the process of heart remodeling with the subsequentdevelopment of myocardial dysfunction and progression of heart failure.