Alarin Level Response to an Oral Glucose Tolerance Test in Subjects with Gestational Diabetes Mellitus

Alarin has been reported to ameliorate insulin resistance in type 2 diabetis mellitus. However, until now, there is noreport examined the relationship between alarin and gestational diabetes mellitus (GDM). Therefore, the purposeof this study is to examine the level of alarin in subjects with and without gestational diabetes mellitus. 30 healthyand 30 gestational diabetes mellitus subjects were recruited for this study. A 2-hour 75 g oral glucose tolerancetest (OGTT) was performed at 24–28 weeks of pregnancy. GDM were diagnosed using nationally endorsed criteria(fasting [FPG], 1- or 2-hour blood glucose [at least one abnormal value]. Plasma alarin level was measured byELISA. Plasma alarin levels were significantly higher GDM subjects than in healthy individuals (12. 3±1.4 ng/mL vs7.8±0.8 ng/mL; p < .05).1- (18. 8±1.9 ng/mL) and 2-hour (24. 2±3.1 ng/mL) alarin levels in women with GDM weresignificantly increased at OGTT compared with women without GDM [1- (9.4±0.9 ng/mL); 2- (9.7±0.6 ng/mL)].Plasma alarin positively correlated with FBG, HbA1c, HOMA-IR and insulin). The above results suggest that alarinmight be associated in the pathogenesis of gestational diabetes mellitus.